Action-potential-encoded second-harmonic generation as an ultrafast local probe for nonintrusive membrane diagnostics.
نویسندگان
چکیده
The Hodgkin-Huxley treatment of the dynamics of a nerve impulse on a cell membrane is combined with a phenomenological description of molecular hyperpolarizabilities to develop a closed-form model of an action-potential-sensitive second-harmonic response of membrane-bound chromophores. This model is employed to understand the key properties of the map between the action potential and modulation of the second harmonic from a cell membrane stained with hyperpolarizable chromophore molecules.
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عنوان ژورنال:
- Physical review. E, Statistical, nonlinear, and soft matter physics
دوره 81 3 Pt 1 شماره
صفحات -
تاریخ انتشار 2010